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(12) M Macvanin, Z Gluvic, J Radovanovic, M Essack, et al (2023) New insights on the cardiovascular effects of IGF-1 Frontiers in Endocrinology (Lausanne), 2023 Feb 9, Volume 14, Page 1142644

Transformations of dependent variables were applied to achieve a normal distribution when needed

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This actin-binding activity enables rapid cytoskeletal reorganization, which is crucial for: Directed cell migration toward sites of injury Angiogenesis, supporting blood supply to regenerating tissue Fibroblast activation and extracellular matrix (ECM) remodeling Anti-fibrotic effects, limiting excessive scar formation Additional research suggests that TB-500 may also influence gene expression related to cellular survival pathways, oxidative stress responses, and inflammatory cytokine modulation